EU probe of weight loss and diabetes drugs like Wegovy, Ozempic finds no link to suicidal thoughts

European Union drug regulators found no evidence that highly popular weight loss and diabetes drugs such as Wegovy and Ozempic are linked to an increased risk of suicidal thoughts and self-injury, the regulator said Friday. 

The European Medicines Agency conducted a nine-month investigation into so-called GLP-1s, a blockbuster class of treatments that mimic a hormone produced in the gut to suppress a person's appetite. Those drugs have skyrocketed in demand over the last year despite their hefty price tags and spotty insurance coverage.

The review examined several drugs from Novo Nordisk, including Wegovy and Ozempic. It did not include Eli Lilly's Zepbound and Mounjaro, two versions of the same drug sold for weight loss and diabetes. But the probe did include the active ingredient in an older diabetes treatment from Eli Lilly called Trulicity. 

In a statement to CNBC, Novo Nordisk confirmed the findings of the EMA's investigation and said it will continue to monitor reports of adverse reactions to its GLP-1s, including suicide and suicidal ideation.

The agency's verdict is the latest in a series of reassuring reports on suicide risk for GLP-1s. The U.S. Food and Drug Administration came to a similar conclusion in January but said agency officials couldn't definitively rule out that a "small risk may exist." 

Clinical trials from Novo Nordisk and Eli Lilly have not demonstrated a link between GLP-1s and suicidal thoughts. Still, researchers and doctors have been on the lookout for any new unwanted side effects or added risks as thousands of new patients start taking the drugs. 

The EMA first launched its investigation in July after the Icelandic Medicines Agency flagged three cases of suicidal thoughts and self-injury in