CNBC Daily Open: S&P 500 briefly crosses 5,500, closes lower

This report is from today's CNBC Daily Open, our international markets newsletter. CNBC Daily Open brings investors up to speed on everything they need to know, no matter where they are. Like what you see? You can subscribe  here .

S&P 500 slips from record high
The S&P 500 briefly passed the 5,500 mark for the first time before ending the session lower. The Nasdaq Composite dipped as Nvidia ran out of steam. The Dow Jones Industrial Average bucked the trend, recording its best day since May. The yield on the 10-year Treasury rose. U.S. oil prices traded above $82 a barrel and are on track for their second straight week of gains.

HIV shot
Gilead Sciences' shares surged 7% after the company announced its experimental twice-yearly HIV prevention medicine demonstrated 100% effectiveness in a late-stage trial. None of the nearly 2,000 women who got the lenacapavir shot in the trial had contracted HIV, an interim analysis showed. The independent data monitoring committee has recommended Gilead to offer the treatment to all the participants in the study.

Open AI challenger
Anthropic, a leading AI competitor to OpenAI, unveiled Claude 3.5 Sonnet, its most advanced AI model to date. Backed by tech giants Google, Salesforce and Amazon, Anthropic closed five funding deals totaling about $7.3 billion in the past year. Claude 3.5 Sonnet "shows marked improvement in grasping nuance, humor, and complex instructions, and is exceptional at writing high-quality content with a natural, relatable tone," the company said in a blog post.

Trump Media shares sinks
Former President Donald Trump's stake in Trump Media has plummeted by over $2 billion, falling from $5.6 billion at the beginning of the month. The company, which owns Truth Social, saw